Sitagliptin phosphate

Name: Sitagliptin phosphate
Brand: Tocris Bioscience
SKU: 6816

Tocris Bioscience, part of Bio-Techne | Catalog # 6816

Citations (1)

COA / SDS

Potent and selective DPP IV inhibitor

Key Product Details

Description:	Potent and selective DPP IV inhibitor
Chemical Name:	(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	505.31

View Full Technical Details for Sitagliptin phosphate

Technical Data
Citations

Biological Activity for Sitagliptin phosphate

Sitagliptin phosphate is a potent and selective DPP IV (DPP4) inhibitor (IC₅₀ = 18 nM). Displays >2600-fold selectivity for DPP IV over other proline specific peptidases. Reduces blood glucose and increases GLP-1 levels after oral glucose tolerance test in normal and diet-induced obese mice.

Compound Libraries for Sitagliptin phosphate

Sitagliptin phosphate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sitagliptin phosphate

M. Wt	505.31
Formula	C₁₆H₁₅F₆N₅O.H₃O₄P
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	654671-78-0
PubChem ID	6451150
InChi Key	IQFYVLUXQXSJJN-SBSPUUFOSA-N
Smiles	OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sitagliptin phosphate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.27	50
	DMSO	25.27	50

Preparing Stock Solutions for Sitagliptin phosphate

The following data is based on the product molecular weight 505.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.96 mL	19.79 mL	39.58 mL
2.5 mM	0.79 mL	3.96 mL	7.92 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
25 mM	0.08 mL	0.40 mL	0.79 mL

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Reconstitution Calculator

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References for Sitagliptin phosphate

References are publications that support the biological activity of the product.

Kim (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 2005 PMID: 15634008