SJFδ

Name: SJFδ
Brand: Tocris Bioscience
SKU: 7267

Tocris Bioscience, part of Bio-Techne | Catalog # 7267

COA / SDS

Potent and selective p38δ PROTAC®

Key Product Details

Description:	Potent and selective p38δ PROTAC^®
Chemical Name:	N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1168.28

View Full Technical Details for SJFδ

Technical Data
Citations

Biological Activity for SJFδ

SJFδ is a potent and selective PROTAC ^® Degrader of p38δ (DC₅₀ = 46.17 nM; D_max = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for SJFδ

M. Wt	1168.28
Formula	C₆₂H₆₃F₂N₇O₁₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2254609-23-7
PubChem ID	137628678
InChi Key	LYUUIIZKBMBNQV-CHOFKVETSA-N
Smiles	COC1=CC2=C(C=C1OCCOCCOCCOC1=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C=CC(=C1)C1=C(C)N=CS1)N=CC=C2OC1=C(F)C=C(NC(=O)C2(CC2)C(=O)NC2=CC=C(F)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJFδ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	58.41	50

Preparing Stock Solutions for SJFδ

The following data is based on the product molecular weight 1168.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.71 mL	8.56 mL	17.12 mL
2.5 mM	0.34 mL	1.71 mL	3.42 mL
5 mM	0.17 mL	0.86 mL	1.71 mL
25 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SJFδ

References are publications that support the biological activity of the product.

Smith Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 2019 PMID: 30631068