SKI II

Name: SKI II
Brand: Tocris Bioscience
SKU: 2097

Tocris Bioscience, part of Bio-Techne | Catalog # 2097

Citations (30)

COA / SDS

Selective non-lipid inhibitor of sphingosine kinase

Key Product Details

Description:	Selective non-lipid inhibitor of sphingosine kinase
Chemical Name:	4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	302.78

View Full Technical Details for SKI II

Technical Data
Citations

Biological Activity for SKI II

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC₅₀ = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9 - 4.6 μM).

Technical Data for SKI II

M. Wt	302.78
Formula	C₁₅H₁₁ClN₂OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	312636-16-1
PubChem ID	753704
InChi Key	ZFGXZJKLOFCECI-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKI II

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.28	100

Preparing Stock Solutions for SKI II

The following data is based on the product molecular weight 302.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.30 mL	16.51 mL	33.03 mL
5 mM	0.66 mL	3.30 mL	6.61 mL
10 mM	0.33 mL	1.65 mL	3.30 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for SKI II

References are publications that support the biological activity of the product.

French Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res.
French Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 2006 PMID: 16632640