SL 0101-1

Name: SL 0101-1
Brand: Tocris Bioscience
SKU: 2250

Tocris Bioscience, part of Bio-Techne | Catalog # 2250

Citations (11)

COA / SDS

Selective ribosomal S6 kinase (RSK) inhibitor

Key Product Details

Description:	Selective ribosomal S6 kinase (RSK) inhibitor
Chemical Name:	3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
Purity:	≥95% (HPLC)
Molecular Weight:	516.46

View Full Technical Details for SL 0101-1

Technical Data
Citations

Biological Activity for SL 0101-1

SL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

Technical Data for SL 0101-1

M. Wt	516.46
Formula	C₂₅H₂₄O₁₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	77307-50-7
PubChem ID	14825856
InChi Key	SXOZSDJHGMAEGZ-UHFFFAOYSA-N
Smiles	O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SL 0101-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.16	10

Preparing Stock Solutions for SL 0101-1

The following data is based on the product molecular weight 516.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.36 mL	96.81 mL	193.63 mL
0.5 mM	3.87 mL	19.36 mL	38.73 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

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References for SL 0101-1

References are publications that support the biological activity of the product.

Saha RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem.J. 2012 PMID: 22827337
Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214
Godeny and Sayeski ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol.
Smith Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 PMID: 15705904