SL 327

Name: SL 327
Brand: Tocris Bioscience
SKU: 1969

Tocris Bioscience, part of Bio-Techne | Catalog # 1969

Citations (73)

COA / SDS

Selective inhibitor of MEK1 and MEK2; brain penetrant

Key Product Details

Chemical Name:	α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Purity:	≥99%
Molecular Weight:	335.35 kDa

View Full Technical Details for SL 327

Technical Data
Citations

Biological Activity for SL 327

SL 327 is a selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Technical Data for SL 327

M. Wt	335.35 kDa
Formula	C₁₆H₁₂F₃N₃S
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	305350-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SL 327

Solubility

Soluble Soluble to 50 mM in ethanol and to 100 mM in DMSO

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References for SL 327

References are publications that support the biological activity of the product.

A Diaz, P Merino, LG Manrique, JP Ospina, L Cheng, F Wu, V Jeanneret, M Yepes A Cross-talk Between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain J. Neurosci., 2017;0(0):. 2017 PMID: 28931568
F Altmüller, S Pothula, A Annamneedi, S Nakhei-Rad, C Montenegro, E Pina-Ferná, C Marini, M Santos, D Schanze, D Montag, MR Ahmadian, O Stork, M Zenker, A Fejtova Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy PLoS Genet, 2017;13(3):e1006684. 2017 PMID: 28346493
Davis et al. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci., 2000;20:4563 PMID: 10844026
Scherle et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem., 2000;275:37086 PMID: 10969080
Wang et al. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther., 2003;304:172 PMID: 12490588
Atkins et al. The MAPK cascade is required for mammalian associative learning. Nature Neurosci., 1998;1:602