SLM 6031434 hydrochloride

Name: SLM 6031434 hydrochloride
Brand: Tocris Bioscience
SKU: 6281

Tocris Bioscience, part of Bio-Techne | Catalog # 6281

COA / SDS

Selective sphingosine kinase 2 (Sphk2) inhibitor

Key Product Details

Description:	Selective sphingosine kinase 2 (Sphk2) inhibitor
Chemical Name:	(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	489.96

View Full Technical Details for SLM 6031434 hydrochloride

Technical Data
Citations

Biological Activity for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is a Sphk2 inhibitor (K_i = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Compound Libraries for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SLM 6031434 hydrochloride

M. Wt	489.96
Formula	C₂₂H₃₀F₃N₅O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1897379-34-8
PubChem ID	134812833
InChi Key	YIGAQKBPLMSWOD-LMOVPXPDSA-N
Smiles	CCCCCCCCOC1=C(C(F)(F)F)C=C(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SLM 6031434 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.8	20
	DMSO	49	100

Preparing Stock Solutions for SLM 6031434 hydrochloride

The following data is based on the product molecular weight 489.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.20 mL	20.41 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for SLM 6031434 hydrochloride

References are publications that support the biological activity of the product.

Schwalm Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 2021 PMID: 33301900
Kharel Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 2015 PMID: 26243740