SM 324405

Name: SM 324405
Brand: Tocris Bioscience
SKU: 5445

Tocris Bioscience, part of Bio-Techne | Catalog # 5445

COA / SDS

Potent TLR7 agonist

Key Product Details

Description:	Potent TLR7 agonist
Chemical Name:	Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
Purity:	≥98% (HPLC)
Molecular Weight:	385.42

View Full Technical Details for SM 324405

Technical Data
Citations

Biological Activity for SM 324405

SM 324405 is a potent TLR7 agonist (EC₅₀ = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t_½ = 2.6 min in human plasma).

Compound Libraries for SM 324405

SM 324405 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SM 324405

M. Wt	385.42
Formula	C₁₉H₂₃N₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	677773-91-0
PubChem ID	23079483
InChi Key	MXILFZWMVNDOIZ-UHFFFAOYSA-N
Smiles	NC1=NC(OCCCC)=NC(N2CC3=CC=CC(CC(OC)=O)=C3)=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SM 324405

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.54	100

Preparing Stock Solutions for SM 324405

The following data is based on the product molecular weight 385.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.97 mL	25.95 mL
5 mM	0.52 mL	2.59 mL	5.19 mL
10 mM	0.26 mL	1.30 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for SM 324405

References are publications that support the biological activity of the product.

Biffen Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 2012 PMID: 22122192
Kurimoto Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 2010 PMID: 20232824