SN-6

Name: SN-6
Brand: Tocris Bioscience
SKU: 2184

Tocris Bioscience, part of Bio-Techne | Catalog # 2184

Citations (58)

COA / SDS

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

Key Product Details

Chemical Name:	2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Purity:	≥99%
Molecular Weight:	402.16 kDa

View Full Technical Details for SN-6

Technical Data
Citations

Biological Activity for SN-6

SN-6 is a selective Na⁺/Ca²⁺-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC₅₀ values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent ⁴⁵Ca²⁺ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC₅₀ = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC₅₀ > 30 μM). Preferentially blocks Ca²⁺ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC₅₀ = 0.63 μM).

Technical Data for SN-6

M. Wt	402.16 kDa
Formula	C₂₀H₂₂N₂O₅S
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	415697-08-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SN-6

Solubility

Soluble Soluble to 100 mM in DMSO

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References for SN-6

References are publications that support the biological activity of the product.

Iwamoto et al. The exchanger inhibitory peptide region-dependent inhibition of Na⁺/Ca²+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol.Pharmacol., 2004;66:45 PMID: 15213295
Iwamoto Forefront of Na⁺/Ca²⁺ exchanger studies: molecular pharmacology of N⁺/Ca²⁺ exchange inhibitors. J.Pharmacol.Sci., 2004;96:27 PMID: 15359084