Sodium Cromoglicate

Name: Sodium Cromoglicate
Brand: Tocris Bioscience
SKU: 6424

Tocris Bioscience, part of Bio-Techne | Catalog # 6424

COA / SDS

Promotes ESCs/iPSCs differentiation into pancreatic endocrine islet cells

Key Product Details

Description:	Promotes ESCs/iPSCs differentiation into pancreatic endocrine islet cells
Chemical Name:	5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	512.33

View Full Technical Details for Sodium Cromoglicate

Technical Data
Citations

Biological Activity for Sodium Cromoglicate

Sodium Cromoglicate is a promotes transformation ESCs/iPSCs into pancreatic endocrine islet cells. Facilitates differentiation from endocrine precursors. Also inhibits mast cell degranulation and histamine release. Antiasthmatic.

Technical Data for Sodium Cromoglicate

M. Wt	512.33
Formula	C₂₃H₁₄Na₂O₁₁
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	15826-37-6
PubChem ID	27503
InChi Key	VLARUOGDXDTHEH-UHFFFAOYSA-L
Smiles	OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sodium Cromoglicate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25.62	50

Preparing Stock Solutions for Sodium Cromoglicate

The following data is based on the product molecular weight 512.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.90 mL	19.52 mL	39.04 mL
2.5 mM	0.78 mL	3.90 mL	7.81 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References for Sodium Cromoglicate

References are publications that support the biological activity of the product.

Kondo Identification of a small molecule that facilitates the differentiation of human iPSCS/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 2017 PMID: 28534195
Orr and Cox Disodium Cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature. 1969 PMID: 4183038