Sorafenib

Name: Sorafenib
Brand: Tocris Bioscience
SKU: 6814

Tocris Bioscience, part of Bio-Techne | Catalog # 6814

Citations (13)

COA / SDS

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

Key Product Details

Description:	Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
Chemical Name:	4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	464.82

View Full Technical Details for Sorafenib

Technical Data
Citations

Biological Activity for Sorafenib

Sorafenib is a potent Raf inhibitor (IC₅₀ values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC₅₀ values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.

Compound Libraries for Sorafenib

Sorafenib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sorafenib

M. Wt	464.82
Formula	C₂₁H₁₆ClF₃N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	284461-73-0
PubChem ID	216239
InChi Key	MLDQJTXFUGDVEO-UHFFFAOYSA-N
Smiles	CNC(C1=CC(OC2=CC=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sorafenib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.3	20

Preparing Stock Solutions for Sorafenib

The following data is based on the product molecular weight 464.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.76 mL	53.78 mL	107.57 mL
1 mM	2.15 mL	10.76 mL	21.51 mL
2 mM	1.08 mL	5.38 mL	10.76 mL
10 mM	0.22 mL	1.08 mL	2.15 mL

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References for Sorafenib

References are publications that support the biological activity of the product.

Lachaier Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res. 2014 PMID: 25368241
Wilhelm BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 PMID: 15466206