SP 141

Name: SP 141
Brand: Tocris Bioscience
SKU: 5332

Tocris Bioscience, part of Bio-Techne | Catalog # 5332

Citations (3)

COA / SDS

High affinity MDM2 inhibitor

Key Product Details

Chemical Name:	6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity:	≥98%

View Full Technical Details for SP 141

Technical Data
Citations

Biological Activity for SP 141

SP 141 is a high affinity MDM2 inhibitor (K_i = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Technical Data for SP 141

Formula	C₂₂H₁₆N₂O
Storage	Store at +4°C
Purity	≥98%
CAS Number	1253491-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SP 141

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for SP 141

References are publications that support the biological activity of the product.

Wang et al. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun., 2014;5:5086 PMID: 25271708

SP 141

Tocris Bioscience, part of Bio-Techne | Catalog # 5332

Key Product Details

Biological Activity for SP 141

Technical Data for SP 141

Solubility for SP 141

Dilution Calculator

Reconstitution Calculator

References for SP 141

Product Documents for SP 141

COA

Certificate of Analysis

SDS

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