Spadin

Name: Spadin
Brand: Tocris Bioscience
SKU: 5594
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5594

(1)

Citations (13)

COA / SDS

Potent K2P2.1 (TREK-1) channel blocker

Key Product Details

Description:	Potent K_2P2.1 (TREK-1) channel blocker
Purity:	≥95% (HPLC)
Molecular Weight:	2012.34

View Full Technical Details for Spadin

Technical Data
Citations / Reviews (1)

Biological Activity for Spadin

Spadin is a potent TREK-1 channel blocker (IC₅₀ = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.

Technical Data for Spadin

M. Wt	2012.34
Formula	C₉₆H₁₄₂N₂₆O₂₂
Single Letter Sequence	YAPLPRWSGPIGVSWGLR
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1270083-24-3
PubChem ID	91826106
InChi Key	WMSPWLIEKXALQP-WSSJNERPSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Spadin

Solubility

Soluble to 2mg/ml in water

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References for Spadin

References are publications that support the biological activity of the product.

Borsotto Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br.J.Pharmacol. 2015 PMID: 25263033
Mazella Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 PMID: 20405001