SPT Imidazopyridine 1

Name: SPT Imidazopyridine 1
Brand: Tocris Bioscience
SKU: 6055

Tocris Bioscience, part of Bio-Techne | Catalog # 6055

COA / SDS

Potent serine palmitoyl transferase inhibitor

Key Product Details

Description:	Potent serine palmitoyl transferase inhibitor
Chemical Name:	4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid
Purity:	≥98%
Molecular Weight:	364.44

View Full Technical Details for SPT Imidazopyridine 1

Technical Data
Citations

Biological Activity for SPT Imidazopyridine 1

SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC₅₀ = 5 nM). Dose-dependently inhibits incorporation of ¹⁴C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.

Technical Data for SPT Imidazopyridine 1

M. Wt	364.44
Formula	C₂₂H₂₄N₂O₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	1933533-18-6
PubChem ID	131954583
InChi Key	MMYRYMMKMUTPBB-UHFFFAOYSA-N
Smiles	CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(C=C3)CC(O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SPT Imidazopyridine 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.44	100

Preparing Stock Solutions for SPT Imidazopyridine 1

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for SPT Imidazopyridine 1

References are publications that support the biological activity of the product.

Genin Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 2016 PMID: 27213958