SR 12813

Name: SR 12813
Brand: Tocris Bioscience
SKU: 2969

Tocris Bioscience, part of Bio-Techne | Catalog # 2969

Citations (6)

COA / SDS

Pregnane X receptor agonist

Key Product Details

Description:	Pregnane X receptor agonist
Chemical Name:	[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	504.53

View Full Technical Details for SR 12813

Technical Data
Citations

Biological Activity for SR 12813

SR 12813 is a pregnane X receptor (PXR) agonist (EC₅₀ values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.

Technical Data for SR 12813

M. Wt	504.53
Formula	C₂₄H₄₂O₇P₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	126411-39-0
PubChem ID	446313
InChi Key	YQLJDECYQDRSBI-UHFFFAOYSA-N
Smiles	OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 12813

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.45	100
	ethanol	50.45	100

Preparing Stock Solutions for SR 12813

The following data is based on the product molecular weight 504.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for SR 12813

References are publications that support the biological activity of the product.

Lemaire Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Mol.Pharmacol. 2007 PMID: 17573484
Jones The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol.Pharmacol.
Berkhout The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J.Biol.Chem. 1996 PMID: 8662919