SR 140333

Name: SR 140333
Brand: Tocris Bioscience
SKU: 4012

Tocris Bioscience, part of Bio-Techne | Catalog # 4012

Citations (12)

COA / SDS

Potent NK1 antagonist

Key Product Details

Description:	Potent NK₁ antagonist
Chemical Name:	1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
Purity:	≥97% (HPLC)
Molecular Weight:	656.12

View Full Technical Details for SR 140333

Technical Data
Citations

Biological Activity for SR 140333

SR 140333 is a potent NK₁ receptor antagonist (K_i = 0.74 nM. IC₅₀ = 1.6 nM). Inhibits substance P-invoked calcium mobilization and outward current (IC₅₀ = 1.3 nM); blocks NK₁-mediated nitric oxide-dependent vasodilation in vivo.

Compound Libraries for SR 140333

SR 140333 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 140333

M. Wt	656.12
Formula	C₃₇H₄₅Cl₃N₂O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	153050-21-6
PubChem ID	108166
InChi Key	NQHFSECYQAQZBN-LSYPWIJNSA-M
Smiles	O=C(N2C[C@@](CC[N+]3(CC5)CCC(C4=CC=CC=C4)5CC3)([C@]6=CC=C(Cl)C(Cl)=C6)CCC2)CC1=CC(OC(C)C)=CC=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 140333

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	65.61	100
	ethanol	65.61	100

Preparing Stock Solutions for SR 140333

The following data is based on the product molecular weight 656.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.62 mL	15.24 mL
5 mM	0.30 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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References for SR 140333

References are publications that support the biological activity of the product.

Emonds-Alt In vitro and in vivo biological activities of SR140333, a novel non-peptide tachykinin NK₁ receptor antagonist. Eur.J.Pharmacol. 1993 PMID: 7509286
Nieuwmeyer Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of Caj J.Pharmacol.Exp.Ther. 2006 PMID: 16330493
Oury-Donat SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J.Neurochem. 1994 PMID: 7510780
Hall and Brain Inhibition by SR140333 of NK₁ tachykinin receptor-evoked, nitric oxide-dependent vasodilation in the hamster cheek pouch microvasculature in vivo. Br.J.Pharmacol. 1994 PMID: 7530573