SR 141716A

Name: SR 141716A
Brand: Tocris Bioscience
SKU: 0923

Tocris Bioscience, part of Bio-Techne | Catalog # 0923

(2)

Citations (120)

COA / SDS

Selective CB1 inverse agonist

Key Product Details

Chemical Name:	N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
Purity:	≥99%

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Technical Data
Citations / Reviews (2)

Biological Activity for SR 141716A

SR 141716A is a potent and selective cannabinoid CB₁ receptor antagonist (K_i= 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC₅₀ = 48 nM). Displays no activity at CB₂ receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also μ-opioid receptor antagonist (K_i = 652 nm)

Technical Data for SR 141716A

Formula	C₂₂H₂₁Cl₃N₄O.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	158681-13-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 141716A

Solubility

Soluble Soluble to 100 mM in DMSO

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References for SR 141716A

References are publications that support the biological activity of the product.

Colombo et al. Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci., 1998;63:113 PMID: 9718088
Janiak et al. Blockade of cannabinoid CB₁ receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats. Kidney Int., 2007;72:1345 PMID: 17882151
Rinaldi-Carmona et al. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett., 1994;350:240 PMID: 8070571
Rinaldi-Carmona et al. Biochemical and pharmacological characterisation of SR 141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci., 1995;56:1941 PMID: 7776817
Seely et al. AM-251 and rimon. act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology, 2012;63:905 PMID: 22771770

SR 141716A

Tocris Bioscience, part of Bio-Techne | Catalog # 0923

Key Product Details

Biological Activity for SR 141716A

Technical Data for SR 141716A

Solubility for SR 141716A

Dilution Calculator

Reconstitution Calculator

References for SR 141716A

Product Documents for SR 141716A

COA

Certificate of Analysis

SDS

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