SR 16584

Name: SR 16584
Brand: Tocris Bioscience
SKU: 4424

Tocris Bioscience, part of Bio-Techne | Catalog # 4424

Citations (5)

COA / SDS

Selective α3β4 nAChR antagonist

Key Product Details

Description:	Selective α3β4 nAChR antagonist
Chemical Name:	1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.37

View Full Technical Details for SR 16584

Technical Data
Citations

Biological Activity for SR 16584

SR 16584 is a selective α3β4 nAChR antagonist (IC₅₀ = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (K_i values are 0.508, >100 and >100 μM, respectively).

Technical Data for SR 16584

M. Wt	270.37
Formula	C₁₇H₂₂N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1150153-86-8
PubChem ID	42602880
InChi Key	GIDZCNCCCWFCIN-UHFFFAOYSA-N
Smiles	O=C(CC3=C2C=CC=C3)N2[C@H]1C[C@@H](N4C)CCC[C@@H]4C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 16584

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.04	100

Preparing Stock Solutions for SR 16584

The following data is based on the product molecular weight 270.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.49 mL	36.99 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for SR 16584

References are publications that support the biological activity of the product.

Zaveri Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 2012 PMID: 20979364