SR 3677 dihydrochloride

Name: SR 3677 dihydrochloride
Brand: Tocris Bioscience
SKU: 3667

Tocris Bioscience, part of Bio-Techne | Catalog # 3667

Citations (2)

COA / SDS

Potent, selective Rho-kinase (ROCK) inhibitor

Key Product Details

Description:	Potent, selective Rho-kinase (ROCK) inhibitor
Chemical Name:	N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	481.37

View Full Technical Details for SR 3677 dihydrochloride

Technical Data
Citations

Biological Activity for SR 3677 dihydrochloride

SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC₅₀ values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

Compound Libraries for SR 3677 dihydrochloride

SR 3677 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SR 3677 dihydrochloride

M. Wt	481.37
Formula	C₂₂H₂₄N₄O₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1781628-88-3
PubChem ID	90255168
InChi Key	INVVXEKRUDMEBE-UHFFFAOYSA-N
Smiles	O=C(C3COC(C=CC=C4)=C4O3)NC1=CC=C(C2=CNN=C2)C=C1OCCN(C)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 3677 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.49	100
	DMSO	44.49	100

Preparing Stock Solutions for SR 3677 dihydrochloride

The following data is based on the product molecular weight 481.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.77 mL
5 mM	0.42 mL	2.08 mL	4.15 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for SR 3677 dihydrochloride

References are publications that support the biological activity of the product.

Feng Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 2008 PMID: 18834107