SSR 180711 hydrochloride

Name: SSR 180711 hydrochloride
Brand: Tocris Bioscience
SKU: 5559

Tocris Bioscience, part of Bio-Techne | Catalog # 5559

COA / SDS

Selective α7 nAChR partial agonist

Key Product Details

Description:	Selective α7 nAChR partial agonist
Chemical Name:	4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	361.66

View Full Technical Details for SSR 180711 hydrochloride

Technical Data
Citations

Biological Activity for SSR 180711 hydrochloride

SSR 180711 hydrochloride is a partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.

Technical Data for SSR 180711 hydrochloride

M. Wt	361.66
Formula	C₁₄H₁₇BrN₂O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	446031-79-4
PubChem ID	9928899
InChi Key	YNBXNVUZXFMNSJ-UHFFFAOYSA-N
Smiles	O=C(N1C2CCN(CC2)CC1)OC3=CC=C(Br)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SSR 180711 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	36.17	100
	DMSO	36.17	100

Preparing Stock Solutions for SSR 180711 hydrochloride

The following data is based on the product molecular weight 361.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.65 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for SSR 180711 hydrochloride

References are publications that support the biological activity of the product.

Pichat SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 2007 PMID: 16936709
Jones Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 2014 PMID: 24057763