ST 034307

Name: ST 034307
Brand: Tocris Bioscience
SKU: 6271

Tocris Bioscience, part of Bio-Techne | Catalog # 6271

Citations (7)

COA / SDS

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Key Product Details

Description:	Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo
Chemical Name:	6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	297.95

View Full Technical Details for ST 034307

Technical Data
Citations

Biological Activity for ST 034307

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC₅₀ = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca²⁺/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Technical Data for ST 034307

M. Wt	297.95
Formula	C₁₀H₄Cl₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	133406-29-8
PubChem ID	867466
InChi Key	NTDHYMSVCBGQJF-UHFFFAOYSA-N
Smiles	ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ST 034307

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.8	100
	ethanol	5.96	20

Preparing Stock Solutions for ST 034307

The following data is based on the product molecular weight 297.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.78 mL	33.56 mL
5 mM	0.67 mL	3.36 mL	6.71 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ST 034307

References are publications that support the biological activity of the product.

Brust Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 2017 PMID: 28223412