SU 16f

Tocris Bioscience, part of Bio-Techne | Catalog # 3304

COA / SDS

Potent and selective PDGFRβ inhibitor

Key Product Details

Description:	Potent and selective PDGFRβ inhibitor
Chemical Name:	5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	386.44

View Full Technical Details for SU 16f

Technical Data
Citations

Biological Activity for SU 16f

SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC₅₀ = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.

For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Compound Libraries for SU 16f

SU 16f is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SU 16f

M. Wt	386.44
Formula	C₂₄H₂₂N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	251356-45-3
PubChem ID	5329150
InChi Key	APYYTEJNOZQZNA-MOSHPQCFSA-N
Smiles	O=C2NC1=CC(C4=CC=CC=C4)=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 16f

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.64	100

Preparing Stock Solutions for SU 16f

The following data is based on the product molecular weight 386.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.94 mL	25.88 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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Reconstitution Calculator

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References for SU 16f

References are publications that support the biological activity of the product.

Cao Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 2016 PMID: 27127239
Sun Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697