Sumatriptan succinate

Name: Sumatriptan succinate
Brand: Tocris Bioscience
SKU: 3586

Tocris Bioscience, part of Bio-Techne | Catalog # 3586

(1)

Citations (4)

COA / SDS

5-HT1A, 5-HT1B and 5-HT1D agonist

Key Product Details

Chemical Name:	3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Purity:	≥99%
Molecular Weight:	413.49 kDa

View Full Technical Details for Sumatriptan succinate

Technical Data
Citations / Reviews (1)

Biological Activity for Sumatriptan succinate

Sumatriptan succinate is a 5-HT₁ receptor agonist (K_i values are 17, 27 and 100 nM at 5-HT_1D, 5-HT_1B and 5-HT_1A receptors respectively). Antimigraine agent.

Technical Data for Sumatriptan succinate

M. Wt	413.49 kDa
Formula	C₁₄H₂₁N₃O₂S.C₄H₆O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	103628-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sumatriptan succinate

Solubility

Soluble Soluble to 100 mM in water and to 75 mM in DMSO

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References for Sumatriptan succinate

References are publications that support the biological activity of the product.

Peroutka and McCarthy Sumatriptan (GR 43175) interacts selectivity with 5-HT_1B and 5-HT_1D binding sites. Eur.J.Pharmacol., 1989;163:133 PMID: 2545459
Peroutka Sumatriptan in acute migraine: pharmacology and review of world experience. Headache, 1990;30:554 PMID: 2177047
Ottani et al. Effect of sumatr. in different models of pain in rats. Eur.J.Pharmacol., 2004;497:181 PMID: 15306203