SZL P1-41

Name: SZL P1-41
Brand: Tocris Bioscience
SKU: 5076

Tocris Bioscience, part of Bio-Techne | Catalog # 5076

Citations (4)

COA / SDS

Selective Skp2 inhibitor; suppresses E3 ligase activity

Key Product Details

Chemical Name:	3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity:	≥98%

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Technical Data
Citations

Biological Activity for SZL P1-41

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data for SZL P1-41

Formula	C₂₄H₂₄N₂O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	222716-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SZL P1-41

Solubility

Soluble Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming

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References for SZL P1-41

References are publications that support the biological activity of the product.

J Wu, HK Su, ZH Yu, SY Xi, CC Guo, ZY Hu, Y Qu, HP Cai, YY Zhao, HF Zhao, FR Chen, YF Huang, ST To, BH Feng, K Sai, ZP Chen, J Wang Skp2 modulates proliferation, senescence and tumorigenesis of glioma Cancer Cell Int., 2020;20(0):71. 2020 PMID: 32165861
Chan et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell, 2013;154:556 PMID: 23911321

SZL P1-41

Tocris Bioscience, part of Bio-Techne | Catalog # 5076

Key Product Details

Biological Activity for SZL P1-41

Technical Data for SZL P1-41

Solubility for SZL P1-41

Dilution Calculator

Reconstitution Calculator

References for SZL P1-41

Product Documents for SZL P1-41

COA

Certificate of Analysis

SDS

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