T 112

Name: T 112
Brand: Tocris Bioscience
SKU: 7690

Tocris Bioscience, part of Bio-Techne | Catalog # 7690

COA / SDS

Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes

Key Product Details

Description:	Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
Chemical Name:	2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	489.37

View Full Technical Details for T 112

Technical Data
Citations

Biological Activity for T 112

T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.

Licensing Information

Sold under license from Orizuru Therapeutics

Technical Data for T 112

M. Wt	489.37
Formula	C₂₅H₂₁BrN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2376876-87-6
PubChem ID	151597503
InChi Key	QJTVIYLRDQROJD-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C2=NC3=CC=C(N4CC5=CC(N6CCOCC6)=CC=C5C4=O)C=C3N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for T 112

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.89	10

Preparing Stock Solutions for T 112

The following data is based on the product molecular weight 489.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.43 mL	102.17 mL	204.34 mL
0.5 mM	4.09 mL	20.43 mL	40.87 mL
1 mM	2.04 mL	10.22 mL	20.43 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

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References for T 112

References are publications that support the biological activity of the product.

Miki ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 2021 PMID: 34155205