TAK 375

Name: TAK 375
Brand: Tocris Bioscience
SKU: 6777
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6777

(1)

COA / SDS

Very high affinity and selective melatonin receptor agonist

Key Product Details

Description:	Very high affinity and selective melatonin receptor agonist
Alternative Names:	Ramelteon
Chemical Name:	N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	259.34

View Full Technical Details for TAK 375

Technical Data
Citations / Reviews (1)

Biological Activity for TAK 375

TAK 375 is a very high affinity and selective melatonin agonist (K_i values are 14 and 112 pM for human MT₁ and MT₂, respectively). Selective for human MT₁ and MT₂ over hamster MT₃ and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.

Compound Libraries for TAK 375

TAK 375 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TAK 375

M. Wt	259.34
Formula	C₁₆H₂₁NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	196597-26-9
PubChem ID	208902
InChi Key	YLXDSYKOBKBWJQ-LBPRGKRZSA-N
Smiles	CCC(NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 375

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.93	100
	ethanol	25.93	100

Preparing Stock Solutions for TAK 375

The following data is based on the product molecular weight 259.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.86 mL	19.28 mL	38.56 mL
5 mM	0.77 mL	3.86 mL	7.71 mL
10 mM	0.39 mL	1.93 mL	3.86 mL
50 mM	0.08 mL	0.39 mL	0.77 mL

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Reconstitution Calculator

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References for TAK 375

References are publications that support the biological activity of the product.

Hirai Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats J.Biol.Rhythms. 2005 PMID: 15654068
Kato Neurochemical properties of rame. (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005 PMID: 15695169
Stroethoff Melatonin receptor agonist rame. reduces ischemia-reperfusion injury through activation of mitochondrial potassium channels. J.Cardiovasc.Pharmacol. 2018 PMID: 29787401