TAK 715

Name: TAK 715
Brand: Tocris Bioscience
SKU: 4254

Tocris Bioscience, part of Bio-Techne | Catalog # 4254

Citations (6)

COA / SDS

Potent p38 MAPK inhibitor; anti-inflammatory

Key Product Details

Chemical Name:	N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Purity:	≥99%
Molecular Weight:	399.51 kDa

View Full Technical Details for TAK 715

Technical Data
Citations

Biological Activity for TAK 715

TAK 715 is an inhibitor of p38 MAPK (IC₅₀ = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Technical Data for TAK 715

M. Wt	399.51 kDa
Formula	C₂₄H₂₁N₃OS
Storage	Store at +4°C
Purity	≥99%
CAS Number	303162-79-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 715

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for TAK 715

References are publications that support the biological activity of the product.

Miwatashi et al. Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem., 2005;48:5966 PMID: 16162000
Verkaar et al. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol., 2011;18:485 PMID: 21513885