Talabostat mesylate

Name: Talabostat mesylate
Brand: Tocris Bioscience
SKU: 3719

Tocris Bioscience, part of Bio-Techne | Catalog # 3719

Citations (7)

COA / SDS

Potent DPP IV inhibitor; activates NLRP1b inflammasome

Key Product Details

Description:	Potent DPP IV inhibitor; activates NLRP1b inflammasome
Alternative Names:	Val-boroPro,BXCL 701
Chemical Name:	B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	310.18

View Full Technical Details for Talabostat mesylate

Technical Data
Citations

Biological Activity for Talabostat mesylate

Talabostat mesylate is a potent DPP IV inhibitor (IC₅₀ values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

Technical Data for Talabostat mesylate

M. Wt	310.18
Formula	C₉H₁₉BN₂O₃.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	150080-09-4
PubChem ID	11522448
InChi Key	OXYYOEIGQRXGPI-WSZWBAFRSA-N
Smiles	O=C([C@@H](N)C(C)C)N1CCC[C@H]1B(O)O.CS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Talabostat mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.02	100
	DMSO	15.51	50

Preparing Stock Solutions for Talabostat mesylate

The following data is based on the product molecular weight 310.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.12 mL	32.24 mL
5 mM	0.64 mL	3.22 mL	6.45 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Talabostat mesylate

References are publications that support the biological activity of the product.

Okondo Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 2018 PMID: 29396289
Okondo DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 2017 PMID: 27820798