Tamoxifen citrate

Name: Tamoxifen citrate
Brand: Tocris Bioscience
SKU: 0999
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0999

(1)

Citations (17)

COA / SDS

Estrogen receptor partial agonist/antagonist

Key Product Details

Description:	Estrogen receptor partial agonist/antagonist
Chemical Name:	(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Purity:	≥99% (HPLC)
Molecular Weight:	563.65

View Full Technical Details for Tamoxifen citrate

Technical Data
Citations / Reviews (1)

Biological Activity for Tamoxifen citrate

Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat. No. 6432) is also available.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for Tamoxifen citrate

Tamoxifen citrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tamoxifen citrate

M. Wt	563.65
Formula	C₂₆H₂₉NO.C₆H₈O₇
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	54965-24-1
PubChem ID	2733525
InChi Key	FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Smiles	CC/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/C1=CC=C(OCCN(C)C)C=C1.O=C(O)CC(O)(C(O)=O)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tamoxifen citrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.82	5 with gentle warming
	DMSO	56.37	100

Preparing Stock Solutions for Tamoxifen citrate

The following data is based on the product molecular weight 563.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Molarity Calculator

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Reconstitution Calculator

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References for Tamoxifen citrate

References are publications that support the biological activity of the product.

Todorova Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011 PMID: 20383709
Paul Both the immunosuppressant SR31747 and the antioestrogen tamox. bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 1998 PMID: 9618436
Mehta Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 2003 PMID: 12624540
Thomas Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005 PMID: 15539556
Wakeling Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 1984 PMID: 6538611

Product Documents for Tamoxifen citrate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Tamoxifen citrate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov