Tandospirone hydrochloride

Name: Tandospirone hydrochloride
Brand: Tocris Bioscience
SKU: 2854

Tocris Bioscience, part of Bio-Techne | Catalog # 2854

Citations (2)

COA / SDS

Selective 5-HT1A partial agonist

Key Product Details

Chemical Name:	(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥98%
Molecular Weight:	419.95 kDa

View Full Technical Details for Tandospirone hydrochloride

Technical Data
Citations

Biological Activity for Tandospirone hydrochloride

Tandospirone hydrochloride is a 5-HT_1A receptor partial agonist (K_i = 27 nM) that displays selectivity over 5-HT₂, 5-HT_1C, α₁, α₂, D₁ and D₂ receptors (K_i values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT_1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Technical Data for Tandospirone hydrochloride

M. Wt	419.95 kDa
Formula	C₂₁H₂₉N₅O₂.HCl
Storage	Store at +4°C
Purity	≥98%
CAS Number	99095-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tandospirone hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in water

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References for Tandospirone hydrochloride

References are publications that support the biological activity of the product.

Hamik et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry, 1990;28:99 PMID: 1974152
Pollard et al. Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol., 1992;221:297 PMID: 1358655
Matsubara et al. Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res., 2006;1112:126 PMID: 16884702