TAPI 0

Name: TAPI 0
Brand: Tocris Bioscience
SKU: 5523
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5523

Citations (9)

COA / SDS

ADAM-17 (TACE) and MMP inhibitor

Key Product Details

Description:	ADAM-17 (TACE) and MMP inhibitor
Alternative Names:	TNF-α processing inhibitor-0
Chemical Name:	N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Purity:	≥95% (HPLC)
Molecular Weight:	456.54

View Full Technical Details for TAPI 0

Technical Data
Citations

Biological Activity for TAPI 0

TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.

Technical Data for TAPI 0

M. Wt	456.54
Formula	C₂₄H₃₂N₄O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	163958-73-4
PubChem ID	3035404
InChi Key	CRCPLBFLOSEABN-VBSNWNEZSA-N
Smiles	ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAPI 0

Solubility

Soluble to 10mg/ml in DMSO

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References for TAPI 0

References are publications that support the biological activity of the product.

Rzeniewicz L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 2015 PMID: 25775539
Balakrishnan Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 2006 PMID: 16565079