TAPI 2

Name: TAPI 2
Brand: Tocris Bioscience
SKU: 6013

Tocris Bioscience, part of Bio-Techne | Catalog # 6013

Citations (15)

COA / SDS

ADAM-17 (TACE) and MMP inhibitor

Key Product Details

Description:	ADAM-17 (TACE) and MMP inhibitor
Chemical Name:	N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
Purity:	≥95% (HPLC)
Molecular Weight:	415.54

View Full Technical Details for TAPI 2

Technical Data
Citations

Biological Activity for TAPI 2

TAPI 2 is an ADAM-17 (TACE) and MMP inhibitor (K_i = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.

This product is typically reconstituted in water.

Technical Data for TAPI 2

M. Wt	415.54
Formula	C₁₉H₃₇N₅O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	689284-12-6
PubChem ID	10093303
InChi Key	LMIQCBIEAHJAMZ-RMTCENKZSA-N
Smiles	ONC(C[C@@H](CC(C)C)C(N[C@@H](C(C)(C)C)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TAPI 2

References are publications that support the biological activity of the product.

Wang A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via notch1 signaling. Stem Cells Transl.Med. 2016 PMID: 26744411
Moss Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal.Biochem. 2007 PMID: 17548045

TAPI 2

Tocris Bioscience, part of Bio-Techne | Catalog # 6013

Key Product Details

Biological Activity for TAPI 2

Technical Data for TAPI 2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TAPI 2

Product Documents for TAPI 2

COA

Certificate of Analysis

SDS

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