Tasquinimod

Name: Tasquinimod
Brand: Tocris Bioscience
SKU: 7051

Tocris Bioscience, part of Bio-Techne | Catalog # 7051

Citations (2)

COA / SDS

High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic

Key Product Details

Description:	High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic
Chemical Name:	1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	406.36

View Full Technical Details for Tasquinimod

Technical Data
Citations

Biological Activity for Tasquinimod

Tasquinimod is a high affinity negative allosteric modulator of HDAC4 (K_d = 10 - 30 nM). Binds the regulatory Zn²⁺ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro. Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.

Compound Libraries for Tasquinimod

Tasquinimod is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Tasquinimod

M. Wt	406.36
Formula	C₂₀H₁₇F₃N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	254964-60-8
PubChem ID	54682876
InChi Key	ONDYALNGTUAJDX-UHFFFAOYSA-N
Smiles	COC1=C2C(O)=C(C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tasquinimod

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.64	100
	ethanol	8.13	20

Preparing Stock Solutions for Tasquinimod

The following data is based on the product molecular weight 406.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for Tasquinimod

References are publications that support the biological activity of the product.

Isaacs Anti-cancer potency of Tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget 2014 PMID: 25193858
Isaacs Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 PMID: 23149916