Taxol

Name: Taxol
Brand: Tocris Bioscience
SKU: 1097
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1097

(2)

Citations (105)

COA / SDS

Promotes assembly and inhibits disassembly of microtubules

Key Product Details

Description:	Promotes assembly and inhibits disassembly of microtubules
Alternative Names:	Paclitaxel
Chemical Name:	[2aR-[2aα,4β,4aβ,6α,9α(αR,βS),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	853.92

View Full Technical Details for Taxol

Technical Data
Citations / Reviews (2)

Biological Activity for Taxol

Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.

Compound Libraries for Taxol

Taxol is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Taxol

M. Wt	853.92
Formula	C₄₇H₅₁NO₁₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	33069-62-4
PubChem ID	441276
InChi Key	RCINICONZNJXQF-VAZQATRQSA-N
Smiles	O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3O)[C@H](OC(C7=CC=CC=C7)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Taxol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	21.35	25 with gentle warming
	DMSO	85.39	100 with gentle warming

Preparing Stock Solutions for Taxol

The following data is based on the product molecular weight 853.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.17 mL	5.86 mL	11.71 mL
5 mM	0.23 mL	1.17 mL	2.34 mL
10 mM	0.12 mL	0.59 mL	1.17 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Reconstitution Calculator

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References for Taxol

References are publications that support the biological activity of the product.

Nicoletti Antitumor activity of Tax. (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice. Ann.Oncol. 1993 PMID: 8095399
Cross PacT improves outcome from traumatic brain injury. Brain Res. 2015 PMID: 26086366
Rao Characterization of the Tax. binding site on the microtubule. J.Biol.Chem. 1999 PMID: 10608867
Park Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 2004 PMID: 15452117
McGuire Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 1989 PMID: 2569287
Rowinsky Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 1990 PMID: 1973737

Product Documents for Taxol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov