Taxol

Name: Taxol
Brand: Tocris Bioscience
SKU: 1097

Tocris Bioscience, part of Bio-Techne | Catalog # 1097

(2)

Citations (105)

COA / SDS

Promotes assembly and inhibits disassembly of microtubules

Key Product Details

Chemical Name:	[2aR-[2aα,4β,4aβ,6α,9α(αR,βS),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥98%
Molecular Weight:	853.92 kDa

View Full Technical Details for Taxol

Technical Data
Citations / Reviews (2)

Biological Activity for Taxol

Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.

Technical Data for Taxol

M. Wt	853.92 kDa
Formula	C₄₇H₅₁NO₁₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	33069-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Taxol

Solubility

Soluble Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Taxol

References are publications that support the biological activity of the product.

Stephan, Sirkka B, Taber, Alexandr, Jileaeva, Ilona, Pegues, Ericka P, Sentman, Charles, Stephan, Matthias Biopolymer implants enhance the efficacy of adoptive T-cell therapy. Nat Biotechnol, 2015;33(1):97-101. 2015 PMID: 25503382
Del Nagro C, Xiao Y, Rangell L, Reichelt M, O'Brien T Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem, 2014;289(51):35182-92. 2014 PMID: 25355314
Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy. J Immunol, 2015;195(2):726-35. 2015 PMID: 26041539
Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
McGuire et al. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med., 1989;111:273 PMID: 2569287
Rowinsky et al. Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst., 1990;82:1247 PMID: 1973737
Park et al. Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem., 2004;279:51057 PMID: 15452117
Rao et al. Characterization of the Tax. binding site on the microtubule. J.Biol.Chem., 1999;274:37990 PMID: 10608867

Product Documents for Taxol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov