TC 2559 difumarate

Name: TC 2559 difumarate
Brand: Tocris Bioscience
SKU: 2737

Tocris Bioscience, part of Bio-Techne | Catalog # 2737

Citations (2)

COA / SDS

Selective α4β2 nAChR partial agonist

Key Product Details

Description:	Selective α4β2 nAChR partial agonist
Chemical Name:	4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate
Purity:	≥98% (HPLC)
Molecular Weight:	438.43

View Full Technical Details for TC 2559 difumarate

Technical Data
Citations

Biological Activity for TC 2559 difumarate

TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC₅₀ values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)₂(β2)₃ receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.

Technical Data for TC 2559 difumarate

M. Wt	438.43
Formula	C₁₂H₁₈N₂O.2C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2454492-41-0
PubChem ID	56972184
InChi Key	GEWVPSJQGJBDLM-MYBAKCFCSA-N
Smiles	CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC 2559 difumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	43.84	100

Preparing Stock Solutions for TC 2559 difumarate

The following data is based on the product molecular weight 438.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for TC 2559 difumarate

References are publications that support the biological activity of the product.

Chen The nicotinic α4β2 receptor selective agonist, TC-2559, increases DA neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 2003 PMID: 12871651
Zwart 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors. Eur.J.Pharmacol. 2006 PMID: 16674940
Bencherif TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur.J.Pharmacol. 2000 PMID: 11099699