TC-E 5002

Name: TC-E 5002
Brand: Tocris Bioscience
SKU: 5089

Tocris Bioscience, part of Bio-Techne | Catalog # 5089

Citations (2)

COA / SDS

Selective KDM2/7 inhibitor

Key Product Details

Description:	Selective KDM2/7 inhibitor
Chemical Name:	N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
Purity:	≥98% (HPLC)
Molecular Weight:	285.38

View Full Technical Details for TC-E 5002

Technical Data
Citations

Biological Activity for TC-E 5002

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

Compound Libraries for TC-E 5002

TC-E 5002 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-E 5002

M. Wt	285.38
Formula	C₁₅H₂₇NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1453071-47-0
PubChem ID	71735843
InChi Key	NEHSERYKENINRH-UHFFFAOYSA-N
Smiles	O=C(N(CCC(O)=O)O)CCCCCCCCC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-E 5002

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	28.54	100
	DMSO	28.54	100

Preparing Stock Solutions for TC-E 5002

The following data is based on the product molecular weight 285.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.52 mL	35.04 mL
5 mM	0.70 mL	3.50 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TC-E 5002

References are publications that support the biological activity of the product.

Suzuki Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 2013 PMID: 23964788