TC-G 1001

Name: TC-G 1001
Brand: Tocris Bioscience
SKU: 4879

Tocris Bioscience, part of Bio-Techne | Catalog # 4879

COA / SDS

GPR35 agonist; more potent than zaprinast (Cat. No. 0947)

Key Product Details

Description:	GPR35 agonist; more potent than zaprinast (Cat. No. 0947)
Chemical Name:	4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	342.34

View Full Technical Details for TC-G 1001

Technical Data
Citations

Biological Activity for TC-G 1001

TC-G 1001 is a GPR35 agonist (pEC₅₀ values are 7.59 and 8.36 for β-arrestin and Gα_q-i5 Ca²⁺ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).

Technical Data for TC-G 1001

M. Wt	342.34
Formula	C₁₇H₁₁FN₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	494191-73-0
PubChem ID	5766343
InChi Key	SYCKPHBALHXMIR-ZROIWOOFSA-N
Smiles	O=C1N=C(NC3=CC=CC=C3F)S/C1=C\C2=CC=C(C(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-G 1001

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.42	10

Preparing Stock Solutions for TC-G 1001

The following data is based on the product molecular weight 342.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.21 mL	146.05 mL	292.11 mL
0.5 mM	5.84 mL	29.21 mL	58.42 mL
1 mM	2.92 mL	14.61 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL

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References for TC-G 1001

References are publications that support the biological activity of the product.

Neetoo-Isseljee High-throughput identification and characterization of novel, species-selective GPR35 agonists. J.Pharmacol.Exp.Ther. 2013 PMID: 23262279