TC-G 1005

Name: TC-G 1005
Brand: Tocris Bioscience
SKU: 5129

Tocris Bioscience, part of Bio-Techne | Catalog # 5129

Citations (2)

COA / SDS

Potent and selective GPBA receptor (TGR5) agonist

Key Product Details

Description:	Potent and selective GPBA receptor (TGR5) agonist
Chemical Name:	(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	399.48

View Full Technical Details for TC-G 1005

Technical Data
Citations

Biological Activity for TC-G 1005

TC-G 1005 is a potent and selective GPBA agonist (EC₅₀ values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.

Compound Libraries for TC-G 1005

TC-G 1005 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-G 1005

M. Wt	399.48
Formula	C₂₅H₂₅N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1415407-60-1
PubChem ID	71450251
InChi Key	JQULIQJSYPZQMA-UHFFFAOYSA-N
Smiles	CC1=CC(OC2=CC=NC=C2C(N3C(C=CC=C4)=C4N(C5CC5)CC3)=O)=C(C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-G 1005

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.95	100
	ethanol	39.95	100

Preparing Stock Solutions for TC-G 1005

The following data is based on the product molecular weight 399.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.52 mL	25.03 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for TC-G 1005

References are publications that support the biological activity of the product.

Urso Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. Am.J.Physiol.Lung Cell.Mol.Physiol. 2020 PMID: 31800261
Duan Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 2012 PMID: 23148522