TC LPA5 4

Name: TC LPA5 4
Brand: Tocris Bioscience
SKU: 4708
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4708

(1)

Citations (6)

COA / SDS

LPA5 receptor antagonist

Key Product Details

Description:	LPA₅ receptor antagonist
Chemical Name:	5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	410.89

View Full Technical Details for TC LPA5 4

Technical Data
Citations / Reviews (1)

Biological Activity for TC LPA5 4

TC LPA5 4 is an LPA₅ receptor antagonist (IC₅₀ = 0.8 μM in LPA₅-RH7777 cells). TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA₅ against 80 other screened targets.

Compound Libraries for TC LPA5 4

TC LPA5 4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC LPA5 4

M. Wt	410.89
Formula	C₂₃H₂₃ClN₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1393814-38-4
PubChem ID	66552906
InChi Key	BNALUYKEGYUHQC-UHFFFAOYSA-N
Smiles	ClC(C=C(C3=CC(C(O)=O)=NN3C4=CC=CC(OC)=C4)C=C2)=C2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC LPA5 4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.09	100
	ethanol	8.22	20

Preparing Stock Solutions for TC LPA5 4

The following data is based on the product molecular weight 410.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.17 mL	24.34 mL
5 mM	0.49 mL	2.43 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for TC LPA5 4

References are publications that support the biological activity of the product.

Kozian Selective non-lipid modulator of LPA₅ activity in human platelets. Bioorg.Med.Chem.Lett. 2012 PMID: 22801643