TC-N 22A

Name: TC-N 22A
Brand: Tocris Bioscience
SKU: 4370

Tocris Bioscience, part of Bio-Techne | Catalog # 4370

Citations (351)

COA / SDS

Potent and selective positive allosteric modulator of mGlu4 receptors

Discontinued Product

4370 has been discontinued. View all Group III mGluR Modulators products.

Key Product Details

Description:	Potent and selective positive allosteric modulator of mGlu₄ receptors
Chemical Name:	4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	283.35

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Technical Data
Citations

Biological Activity for TC-N 22A

TC-N 22A is a potent and selective mGlu₄ receptor positive allosteric modulator (EC₅₀ = 9 nM in human mGlu₄-expressing BHK cells). Selective for mGlu₄ over mGlu₁, mGlu₂, mGlu₃, mGlu₅ and mGlu₇ receptors (EC₅₀ values are > 10 μM). Brain penetrant.

Technical Data for TC-N 22A

M. Wt	283.35
Formula	C₁₄H₁₃N₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1314140-00-5
PubChem ID	46836562
InChi Key	DBISXWCOHGUFSF-UHFFFAOYSA-N
Smiles	C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TC-N 22A

References are publications that support the biological activity of the product.

Hong Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 2011 PMID: 21688779

TC-N 22A

Tocris Bioscience, part of Bio-Techne | Catalog # 4370

Key Product Details

Biological Activity for TC-N 22A

Technical Data for TC-N 22A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TC-N 22A

Product Documents for TC-N 22A

COA

Certificate of Analysis

SDS

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