TC OT 39

Name: TC OT 39
Brand: Tocris Bioscience
SKU: 4625

Tocris Bioscience, part of Bio-Techne | Catalog # 4625

Citations (2)

COA / SDS

Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist

Key Product Details

Description:	Potent non-peptide oxytocin receptor partial agonist; also V_1a receptor antagonist
Chemical Name:	(2S)-_N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	600.78

View Full Technical Details for TC OT 39

Technical Data
Citations

Biological Activity for TC OT 39

TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC₅₀ values are 33 nM and 850 nM for the oxytocin receptor and V₂ vasopressin receptor respectively). Also a V_1a vasopressin receptor antagonist (K_i = 330 nM). Active in vivo in a rat model of uterine response.

Compound Libraries for TC OT 39

TC OT 39 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC OT 39

M. Wt	600.78
Formula	C₃₂H₄₀N₈O₂S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	479232-57-0
PubChem ID	135413563
InChi Key	KSNHHKZYKYNBEI-NDEPHWFRSA-N
Smiles	O=C(N5[C@H]([C@](N6CCN(C)CCC6)=S)CCC5)NCC(C(C)=C2)=CC=C2C(N1C(C=CC=C3)=C3NC(N(C)N=C4)=C4C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC OT 39

	Solvent	Max Conc. mM
Solubility
	1eq. HCl	100
	DMSO	100

Preparing Stock Solutions for TC OT 39

The following data is based on the product molecular weight 600.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.32 mL	16.65 mL
5 mM	0.33 mL	1.66 mL	3.33 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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References for TC OT 39

References are publications that support the biological activity of the product.

Pitt Non-peptide oxyt. agonists. Bioorg.Med.Chem.Lett. 2004 PMID: 15357997
Frantz Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist. J.Med.Chem. 2010 PMID: 20104850