TC-S 7003

Name: TC-S 7003
Brand: Tocris Bioscience
SKU: 3567

Tocris Bioscience, part of Bio-Techne | Catalog # 3567

Citations (1)

COA / SDS

Potent Lck inhibitor

Key Product Details

Description:	Potent Lck inhibitor
Chemical Name:	6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	530.62

View Full Technical Details for TC-S 7003

Technical Data
Citations

Biological Activity for TC-S 7003

TC-S 7003 is a potent inhibitor of lymphocyte specific kinase (Lck). IC₅₀ values are 0.007, 0.021, 0.042 and 0.20 μM for Lck, Lyn, Src and Syk kinases respectively. Displays >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Inhibits T cell proliferation in vitro and inhibits arthritis in two in vivo models. Orally active.

Compound Libraries for TC-S 7003

TC-S 7003 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7003

M. Wt	530.62
Formula	C₃₁H₃₀N₈O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	847950-09-8
PubChem ID	11785878
InChi Key	BHJJWVDKNXABFS-UHFFFAOYSA-N
Smiles	O=C3N(C4=C(C)C=CC=C4C)C1=NC7=C(C=CC=C7)N1C2=NC(NC5=CC=C(N6CCN(C)CC6)C=C5)=NC=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-S 7003

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.06	100
	ethanol	5.31	10 with gentle warming

Preparing Stock Solutions for TC-S 7003

The following data is based on the product molecular weight 530.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.42 mL	18.85 mL
5 mM	0.38 mL	1.88 mL	3.77 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for TC-S 7003

References are publications that support the biological activity of the product.

Martin Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory J.Med.Chem. 2008 PMID: 18278858