TC-S 7005

Name: TC-S 7005
Brand: Tocris Bioscience
SKU: 4459

Tocris Bioscience, part of Bio-Techne | Catalog # 4459

Citations (6)

COA / SDS

Potent and selective PLK2 inhibitor

Key Product Details

Description:	Potent and selective PLK2 inhibitor
Chemical Name:	3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	359.38

View Full Technical Details for TC-S 7005

Technical Data
Citations

Biological Activity for TC-S 7005

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC₅₀ = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC₅₀ values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Compound Libraries for TC-S 7005

TC-S 7005 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7005

M. Wt	359.38
Formula	C₂₁H₁₇N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1082739-92-1
PubChem ID	24971422
InChi Key	DAAGOCSHXCDWDY-ZDUSSCGKSA-N
Smiles	C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-S 7005

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.94	100

Preparing Stock Solutions for TC-S 7005

The following data is based on the product molecular weight 359.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.91 mL	27.83 mL
5 mM	0.56 mL	2.78 mL	5.57 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for TC-S 7005

References are publications that support the biological activity of the product.

Hanan Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18790636