TCS 1102

Name: TCS 1102
Brand: Tocris Bioscience
SKU: 3818

Tocris Bioscience, part of Bio-Techne | Catalog # 3818

Citations (29)

COA / SDS

Potent, dual orexin receptor antagonist

Key Product Details

Description:	Potent, dual orexin receptor antagonist
Chemical Name:	N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	470.59

View Full Technical Details for TCS 1102

Technical Data
Citations

Biological Activity for TCS 1102

TCS 1102 is a potent, dual orexin receptor antagonist (K_i values are 0.2 and 3 nM for OX₂ and OX₁ receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Technical Data for TCS 1102

M. Wt	470.59
Formula	C₂₇H₂₆N₄O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	916141-36-1
PubChem ID	11960895
InChi Key	YSBGRVXJEMSEQY-DEOSSOPVSA-N
Smiles	O=C(CSC2=NC(C=CC=C5)=C5N2C)N1CCC[C@H]1[C@](NC3=CC=CC=C3C4=CC=CC=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 1102

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.06	100
	ethanol	47.06	100

Preparing Stock Solutions for TCS 1102

The following data is based on the product molecular weight 470.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for TCS 1102

References are publications that support the biological activity of the product.

Bergman Proline bis-amides as potent dual orexin receptor antagonists. Bioorg.Med.Chem.Letts
Khoo The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 2017 PMID: 28296947
Winrow Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 2010 PMID: 19596018