Tenidap

Name: Tenidap
Brand: Tocris Bioscience
SKU: 2580

Tocris Bioscience, part of Bio-Techne | Catalog # 2580

Citations (1)

COA / SDS

NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3

Key Product Details

Chemical Name:	(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
Purity:	≥99%

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Technical Data
Citations

Biological Activity for Tenidap

Tenidap is a NSAID that preferentially inhibits COX-1 (IC₅₀ values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK_ir2.3 channel (EC₅₀ = 402 nM).

Technical Data for Tenidap

Formula	C₁₄H₉N₂O₃SCl
Storage	Store at +4°C
Purity	≥99%
CAS Number	120210-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tenidap

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Tenidap

References are publications that support the biological activity of the product.

Moilanen et al. CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids, 1988;1:35 PMID: 2856170
Kirchner et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther., 1997;282:1094 PMID: 9262379
Liu et al. Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K⁺ channel hKir2.3. Eur.J.Pharmacol., 2002;435:153 PMID: 11821021

Tenidap

Tocris Bioscience, part of Bio-Techne | Catalog # 2580

Key Product Details

Biological Activity for Tenidap

Technical Data for Tenidap

Solubility for Tenidap

Dilution Calculator

Reconstitution Calculator

References for Tenidap

Product Documents for Tenidap

COA

Certificate of Analysis

SDS

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