Tenidap

Name: Tenidap
Brand: Tocris Bioscience
SKU: 2580

Tocris Bioscience, part of Bio-Techne | Catalog # 2580

Citations (1)

COA / SDS

NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3

Key Product Details

Description:	NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of K_IR2.3
Alternative Names:	CP 66248
Chemical Name:	(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	320.75

View Full Technical Details for Tenidap

Technical Data
Citations

Biological Activity for Tenidap

Tenidap is a NSAID that preferentially inhibits COX-1 (IC₅₀ values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK_ir2.3 channel (EC₅₀ = 402 nM).

Compound Libraries for Tenidap

Tenidap is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tenidap

M. Wt	320.75
Formula	C₁₄H₉N₂O₃SCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	120210-48-2
PubChem ID	54683953
InChi Key	LXIKEPCNDFVJKC-QXMHVHEDSA-N
Smiles	O=C1N(C(N)=O)C2=CC=C(Cl)C=C2/C1=C(O)\C3=CC=CS3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tenidap

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.07	100

Preparing Stock Solutions for Tenidap

The following data is based on the product molecular weight 320.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.59 mL	31.18 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Tenidap

References are publications that support the biological activity of the product.

Kirchner Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 1997 PMID: 9262379
Liu Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K⁺ channel hKir2.3. Eur.J.Pharmacol. 2002 PMID: 11821021
Moilanen CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1988 PMID: 2856170