Teniposide

Name: Teniposide
Brand: Tocris Bioscience
SKU: 6975

Tocris Bioscience, part of Bio-Techne | Catalog # 6975

Citations (3)

COA / SDS

DNA topoisomerase II inhibitor; viral transduction enhancer

Key Product Details

Description:	DNA topoisomerase II inhibitor; viral transduction enhancer
Chemical Name:	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity:	≥98% (HPLC)
Molecular Weight:	656.66

View Full Technical Details for Teniposide

Technical Data
Citations

Biological Activity for Teniposide

Teniposide is a DNA topoisomerase II inhibitor and viral transduction enhancer. It induces breaks in double-stranded DNA and prevents DNA repair. Teniposide enhances transduction of recombinant adeno-associated virus 2 (rAAV2) by up to 40-fold in human cells in vitro and by 100-fold in vivo at 24 h post-transduction.

Technical Data for Teniposide

M. Wt	656.66
Formula	C₃₂H₃₂O₁₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	29767-20-2
PubChem ID	452548
InChi Key	NRUKOCRGYNPUPR-QBPJDGROSA-N
Smiles	[H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@]1([H])O[C@]2([H])CO[C@H](O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Teniposide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	65.67	100

Preparing Stock Solutions for Teniposide

The following data is based on the product molecular weight 656.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.61 mL	15.23 mL
5 mM	0.30 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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References for Teniposide

References are publications that support the biological activity of the product.

Yusenko A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci.Rep. 2018 PMID: 30177851
Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738