TFC 007

Name: TFC 007
Brand: Tocris Bioscience
SKU: 5108

Tocris Bioscience, part of Bio-Techne | Catalog # 5108

Citations (3)

COA / SDS

Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor

Key Product Details

Description:	Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Chemical Name:	N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	487.55

View Full Technical Details for TFC 007

Technical Data
Citations

Biological Activity for TFC 007

TFC 007 is a potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC₅₀ = 83 nM). Inhibits PGD₂ production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC₄ synthase, TXA₂ synthase and microsomal prostaglandin E₂ synthase.

Technical Data for TFC 007

M. Wt	487.55
Formula	C₂₇H₂₉N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	927878-49-7
PubChem ID	16040067
InChi Key	NLSSUSRERAMBTA-UHFFFAOYSA-N
Smiles	O=C(C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2)N1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TFC 007

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.76	100

Preparing Stock Solutions for TFC 007

The following data is based on the product molecular weight 487.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.26 mL	20.51 mL
5 mM	0.41 mL	2.05 mL	4.10 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for TFC 007

References are publications that support the biological activity of the product.

Nabe Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 2011 PMID: 21601002