TGN 020

Name: TGN 020
Brand: Tocris Bioscience
SKU: 5425

Tocris Bioscience, part of Bio-Techne | Catalog # 5425

Citations (11)

COA / SDS

Aquaporin 4 (AQP4) channel blocker

Key Product Details

Description:	Aquaporin 4 (AQP4) channel blocker
Chemical Name:	N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	206.22

View Full Technical Details for TGN 020

Technical Data
Citations

Biological Activity for TGN 020

TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC₅₀ = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Compound Libraries for TGN 020

TGN 020 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TGN 020

M. Wt	206.22
Formula	C₈H₆N₄OS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	51987-99-6
PubChem ID	4173511
InChi Key	AGEGZHOPKZFKBP-UHFFFAOYSA-N
Smiles	O=C(NC1=NN=CS1)C2=CN=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TGN 020

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.12	20

Preparing Stock Solutions for TGN 020

The following data is based on the product molecular weight 206.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	24.25 mL	121.23 mL	242.46 mL
1 mM	4.85 mL	24.25 mL	48.49 mL
2 mM	2.42 mL	12.12 mL	24.25 mL
10 mM	0.48 mL	2.42 mL	4.85 mL

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References for TGN 020

References are publications that support the biological activity of the product.

Igarashi Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 2013 PMID: 23462267
Igarashi and Huber Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 2011 PMID: 20924629
Huber Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 2009 PMID: 18182301