TH 5427 hydrochloride

Name: TH 5427 hydrochloride
Brand: Tocris Bioscience
SKU: 6534

Tocris Bioscience, part of Bio-Techne | Catalog # 6534

Citations (1)

COA / SDS

Potent NUDT5 inhibitor

Key Product Details

Description:	Potent NUDT5 inhibitor
Chemical Name:	7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	527.79

View Full Technical Details for TH 5427 hydrochloride

Technical Data
Citations

Biological Activity for TH 5427 hydrochloride

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC₅₀ = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Compound Libraries for TH 5427 hydrochloride

TH 5427 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TH 5427 hydrochloride

M. Wt	527.79
Formula	C₂₀H₂₀Cl₂N₈O₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2253744-57-7
PubChem ID	137919865
Smiles	O=C1N(C)C(C(N(CC2=NN=C(C3=CC(Cl)=C(Cl)C=C3)O2)C(N4CCNCC4)=N5)=C5N1C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TH 5427 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.28	10
	DMSO	10.56	20

Preparing Stock Solutions for TH 5427 hydrochloride

The following data is based on the product molecular weight 527.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.47 mL	47.37 mL	94.73 mL
1 mM	1.89 mL	9.47 mL	18.95 mL
2 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.19 mL	0.95 mL	1.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TH 5427 hydrochloride

References are publications that support the biological activity of the product.

Page Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 2018 PMID: 29343827