Thalidomide 4'-oxyacetamide-alkylC4-azide

Name: Thalidomide 4'-oxyacetamide-alkylC4-azide
Brand: Tocris Bioscience
SKU: 6300

Tocris Bioscience, part of Bio-Techne | Catalog # 6300

COA / SDS

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Key Product Details

Description:	Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Alternative Names:	Azido-Thalidomide
Chemical Name:	N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	428.4

View Full Technical Details for Thalidomide 4'-oxyacetamide-alkylC4-azide

Technical Data
Citations

Biological Activity for Thalidomide 4'-oxyacetamide-alkylC4-azide

Thalidomide 4'-oxyacetamide-alkylC4-azide is a click-activated Thalidomide (Cat.No. 0652); precursor to PROTAC^® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

This product has been recently renamed. The previous name for this product was Azido-Thalidomide

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-oxyacetamide-alkylC4-azide

M. Wt	428.4
Formula	C₁₉H₂₀N₆O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2098488-36-7
PubChem ID	131704500
InChi Key	USWFAZSQVLTHHA-UHFFFAOYSA-N
Smiles	[N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide 4'-oxyacetamide-alkylC4-azide

References are publications that support the biological activity of the product.

Schiedel Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). J.Med.Chem. 2018 PMID: 28379698