Thalidomide 4'-oxyacetamide-PEG4-amine

Name: Thalidomide 4'-oxyacetamide-PEG4-amine
Brand: Tocris Bioscience
SKU: 6468
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6468

Citations (1)

COA / SDS

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Discontinued Product

6468 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description:	Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names:	Thalidomide - linker 2
Chemical Name:	N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	587.02

View Full Technical Details for Thalidomide 4'-oxyacetamide-PEG4-amine

Technical Data
Citations

Biological Activity for Thalidomide 4'-oxyacetamide-PEG4-amine

Thalidomide 4'-oxyacetamide-PEG4-amine is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 2

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-oxyacetamide-PEG4-amine

M. Wt	587.02
Formula	C₂₅H₃₄N₄O₁₀.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2245697-85-0
PubChem ID	134160247
InChi Key	YHQOQBFOLKFJJN-UHFFFAOYSA-N
Smiles	O=C(C1=C(C(OCC(NCCOCCOCCOCCOCCN)=O)=CC=C1)C2=O)N2C(C(N3)=O)CCC3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide 4'-oxyacetamide-PEG4-amine

References are publications that support the biological activity of the product.

Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825
Winter Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 2015 PMID: 25999370